The best nootropics of the Racetam family

There are quite a few members in the piracetam family that are known for having diverse nootropic effects. They can all improve your focus and energy and help you become more productive, but they also improve depression and anxiety! In this post, I would like to get you up to speed on some of the most popular ones. In a Reddit thread on favorite racetams, some of the favorites listed were Aniracetam for its ability to act as an anxiolytic, increase speech fluidity, improve thought organization, as well as recall. Another user felt like it was the best one because they could take it every day and get the benefits without the side effects.
I like Phenylpiracetam a lot since it increases your energy, focus as well as improving motivation.
Piracetam was the first nootropic I ever tried and I liked that it helped me focus more and think more clearly. I and many other users have also noticed that they can see colors more intensely, as well as hear the nuances of music more clearly. At the same time, it is a mild nootropic and it has virtually no side effects.

The mechanism of these nootropics still remains a mystery, but they are thought to affect the GABAergic as well as the glutamate receptor systems. There is evidence that piracetam increases oxygen consumption and the permeability of cells and mitochondrial membranes to Krebs cycle metabolites, which is a way of saying that it “overclocks” your brain to work faster .

Piracetam

Piracetam was the chemical that gave rise to the notion of nootropics. Piracetam is a derivative of the neurotransmitter GABA. There is scientific evidence that piracetam is able to lower anxiety and depression, as well as being able to improve memory

Phenylpiracetam

Phenylpiracetam was developed in the ’80s in the USSR to alleviate the prolonged stress that was experienced by cosmonauts working in space. Phenylpiracetam has both energy and memory-boosting properties, as well as being a potent anxiolytic (stress reliever) and antidepressant. This might not be ideal for a first time user of nootropics as it is quite potent. Personally I would start with piracetam just to see what it feels like.

Pramiracetam

I have to say Pramiracetam is the only Nootropic I’ve taken that lives up to the hype.

u/ThirdHuman

Pramiracetam is a CNS stimulant and a cognitive enhancer. Users on Reddit really like it for its ability to keep you focused and improve thinking abilities.

Aniracetam

Users on Reddit report that Aniracetam makes them feel more lucid and free from anxiety. Great if you are worried about some particular problem that you can’t seem to get started on. With Aniracetam it is much easier to begin to work on difficult problems because of the anxiolytic effect, as well as finish it because of the cognitive enhancement. Some users do not seem to see any effect with doses lower than 2-3 grams, however.

The importance of adding a choline source

Many people add a choline source, e.g. citicoline as it synergizes with the racetam nootropics to give you even better results! Cholines are important parts of your cell membranes that modulate their fluidity and in fact, it is currently thought that much of cognitive enhancement from different nootropics come from these chemicals’ ability to modify membrane fluidity in nerve cells.

Bibliography

Wikipedia. (2020). Phenylpiracetam. In Wikipedia. https://en.wikipedia.org/w/index.php?title=Phenylpiracetam&oldid=943841048
Grau, M., Montero, J. L., & Balasch, J. (1987). Effect of Piracetam on electrocorticogram and local cerebral glucose utilization in the rat. General Pharmacology, 18(2), 205–211. https://doi.org/10.1016/0306-3623(87)90252-7
Nickolson, V. J., & Wolthuis, O. L. (1976). Effect of the acquisition-enhancing drug piracetam on rat cerebral energy metabolism. Comparison with naftidrofuryl and methamphetamine. Biochemical Pharmacology, 25(20), 2241–2244. https://doi.org/10.1016/0006-2952(76)90004-6
Malykh, A. G., & Sadaie, M. R. (2010). Piracetam and Piracetam-Like Drugs. Drugs, 70(3), 287–312. https://doi.org/10.2165/11319230-000000000-00000

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